Boswellin® HBD (D.C) is obtained from the gum exudate of Boswellia serrata trees commonly known as Frankincense.
Boswellin® HBD is standardized to contain:
Efficacy of Boswellin® HBD
Pre-clinical studies
Anti-inflammatory/Anti-arthritic effects
Active components of Boswellin® HBD exert a synergistic effect
The actives, BBA and AKBBA, act synergistically to exert anti‐inflammatory activity efficaciously in reducing joint pain and improving the physical functional ability in patients with osteoarthritis (OA) of knee33.

R1= H; R2= H | : BBA |
R1= COCH3; R2= H | : ABBA |
R1= H; R2,R2= O | : KBBA |
R1= COCH3; R2,R2= O | : AKBBA |
Anti-inflammatory/Anti-arthritic action | |
---|---|
Inhibition | |
Cytokines (inflammatory interleukins: IL-1β, IL-6, IL-15 & IL-17) and TNF-α | BBA |
Reactive oxygen species (ROS) | BBA, AKBBA |
Lipopolysacharide (LPS) | BBA |
Nuclear factor-kB (NF-kB) | BBA, AKBBA |
Human leukocyte elastase (HLE) | BBA, AKBBA |
5-Lipoxygenase(5-LOX) | BBA, AKBBA |
High-sensitivity c-reactive proteins (hs-CRP) |
BBA, AKBBA |
Microsomal prostaglandin e synthase-1 (mPGES-1) | BBA |
Prostaglandin E2(PGE2) | BBA |
Cathepsin (CatG) | BBA, AKBBA |
Activation | |
Endothelial NOS (eNOS)/ Nitric oxide (NO)/ Cyclic guanosine 3', 5'-monophosphate (cGMP) pathways | BBA |

R1= H; R2= H | : BBA |
R1= COCH3; R2= H | : ABBA |
R1= H; R2,R2= O | : KBBA |
R1= COCH3; R2,R2= O | : AKBBA |
Anti-inflammatory/Anti-arthritic action | |
---|---|
Inhibition | |
Cytokines (inflammatory interleukins: IL-1β, IL-6, IL-15 & IL-17) and TNF-α | BBA |
Reactive Oxygen Species (ROS) | BBA, AKBBA |
Lipopolysacharide (LPS) | BBA |
Nuclear factor-kB (NF-kB) | BBA, AKBBA |
Human leukocyte elastase (HLE) | BBA, AKBBA |
5-Lipoxygenase(5-LOX) | BBA, AKBBA |
High-sensitivity C-reactive proteins (hs-CRP) |
BBA, AKBBA |
microsomal Prostaglandin E Synthase-1 (mPGES-1) | BBA |
Prostaglandin E2(PGE2) | BBA |
Cathepsin (CatG) | BBA, AKBBA |
Activation | |
Endothelial NOS (eNOS)/ nitric oxide (NO)/ cyclic guanosine 3', 5'-monophosphate (cGMP) Pathways | BBA |
Anti-inflammtory/Anti-arthritic action
β‐boswellic acid (BBA)
3‐acetyl‐11‐keto‐β‐boswellic acid (AKBBA)
Interleukin (IL)
11‐keto‐β‐boswellic acid (KBBA)
Tumor necrosis factor alpha (TNF‐α)