Boswellin® HBD (D.C) is obtained from the gum exudate of Boswellia serrata trees commonly known as Frankincense.
Boswellin® HBD (D.C) is standardized to contain:
| Total boswellic acids by titration 70.0%- 85.0% w/w | 100% |
| ß-boswellic acids 20.0%- 30.0% w/w | 100% |
| AKBA 2.0% w/w (MIN) | 100% |
| Salient features |
|---|
| 100% natural |
| No preservatives |
| Established safety |
Boswellin® HBD (D.C) is obtained from the gum exudate of Boswellia serrata trees commonly known as Frankincense.
Boswellin® HBD (D.C) is standardized to contain:
Efficacy of Boswellin® HBD
Pre-clinical studies
Anti-inflammatory/Anti-arthritic effects
Active components of Boswellin® HBD exert a synergistic effect
The actives, BBA and AKBBA, act synergistically to exert anti‐inflammatory activity efficaciously in reducing joint pain and improving the physical functional ability in patients with osteoarthritis (OA) of knee33.
| R1= H; R2= H | : BBA |
| R1= COCH3; R2= H | : ABBA |
| R1= H; R2,R2= O | : KBBA |
| R1= COCH3; R2,R2= O | : AKBBA |
| Anti-inflammatory/Anti-arthritic action | |
|---|---|
| Inhibition | |
| Cytokines (inflammatory interleukins: IL-1β, IL-6, IL-15 & IL-17) and TNF-α | BBA |
| Reactive oxygen species (ROS) | BBA, AKBBA |
| Lipopolysacharide (LPS) | BBA |
| Nuclear factor-kB (NF-kB) | BBA, AKBBA |
| Human leukocyte elastase (HLE) | BBA, AKBBA |
| 5-Lipoxygenase(5-LOX) | BBA, AKBBA |
| High-sensitivity c-reactive proteins (hs-CRP) |
BBA, AKBBA |
| Microsomal prostaglandin e synthase-1 (mPGES-1) | BBA |
| Prostaglandin E2(PGE2) | BBA |
| Cathepsin (CatG) | BBA, AKBBA |
| Activation | |
| Endothelial NOS (eNOS)/ Nitric oxide (NO)/ Cyclic guanosine 3′, 5′-monophosphate (cGMP) pathways | BBA |
Anti-inflammtory/Anti-arthritic action
β‐boswellic acid (BBA)
3‐acetyl‐11‐keto‐β‐boswellic acid (AKBBA)
Interleukin (IL)
11‐keto‐β‐boswellic acid (KBBA)
Tumor necrosis factor alpha (TNF‐α)
Anticancer effects
In hepatic cancer cells (Hep G2) treated with KBA and AKBA37
| Both KBA and AKBA induced apoptosis |
| Increased activity of caspase-8 (the initiator of apoptosis) as well as caspase-3 (the executor of apoptosis) |
| Released DNA-histone complex in to the cell cytoplasm |
| Increased percentage of cells in the sub-Gl phase by checking in G1 phase |